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Benzodiazepines are most effective when applied early after a seizure starts, because of alterations at synapses that degrade GABA signaling above time12,13Watch Closely (one)mitotane decreases amounts of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Mitotane is a robust inducer of cytochrome P-450